Kok Fei Chan
Research Fellow Olivia Newton-John Cancer Research Institute
Kok Fei Chan, Research Fellow, Olivia Newton-John Cancer Research Institute, specializes in unconventional gamma delta T cell immunotherapy development. His research focuses on isolating and expanding rare gamma delta T cell subsets (V delta 1, 2, and 3) from healthy donors and cancer patients including triple-negative breast cancer and melanoma. Using proprietary expansion methods, Kok Fei’s team scales cells from thousands to over 100 billion while maintaining therapeutic phenotype and achieving over 90% tumor cell killing in vitro. His work addresses critical challenges in process characterization, automation strategies for scaling, and understanding tumor microenvironment interactions to advance allogeneic cell therapy development.
Seminars
- Identifying donor attributes associated with superior cell fitness to improve clinical efficacy and manufacturing consistency across allogeneic therapies
- Comparing HLA-dependent conventional approaches with MHC-unrestricted γδ T-cell strategies to expand donor accessibility and broaden tumor targeting
- Leveraging donor selection, immune activation and expansion characteristics to overcome tumor evasion mechanisms and enhance therapeutic performance
